Drug interactions
Glipizide-metformin + Methazolamide
Severity: Moderate
Glipizide-metformin and Methazolamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbonic anhydrase inhibitors can cause metabolic acidosis, which may add to the risk of metformin-associated lactic acidosis. This is of particular concern in patients with renal impairment or other risk factors for lactate accumulation.
What this interaction means in plain words
Glipizide-metformin and Methazolamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbonic anhydrase inhibition causes renal bicarbonate loss and hyperchloremic metabolic acidosis, which may add to lactic acidosis risk with metformin.
What to do
Monitor serum bicarbonate, renal function and signs of acidosis, and stop the combination if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Methazolamide?
MediHelp rates the interaction as moderate. Glipizide-metformin and Methazolamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbonic anhydrase inhibitors can cause metabolic acidosis, which may add to the risk of metformin-associated lactic acidosis. This is of particular concern in patients with renal impairment or other risk factors for lactate accumulation.
How serious is the interaction between Glipizide-metformin and Methazolamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, renal function and signs of acidosis, and stop the combination if acidosis develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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