Drug interactions
Glipizide-metformin + Methyclothiazide
Severity: Moderate
Glipizide-metformin and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effect of antidiabetic drugs, so control may worsen when methyclothiazide is added. Competition for renal tubular secretion may also modestly raise metformin exposure.
What this interaction means in plain words
Glipizide-metformin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides cause hypokalemia and impair insulin secretion and sensitivity, and may compete with metformin for renal cationic tubular secretion.
What to do
Monitor blood glucose and HbA1c after starting the diuretic and adjust antidiabetic therapy as needed. Monitor renal function and potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Methyclothiazide?
MediHelp rates the interaction as moderate. Glipizide-metformin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effect of antidiabetic drugs, so control may worsen when methyclothiazide is added. Competition for renal tubular secretion may also modestly raise metformin exposure.
How serious is the interaction between Glipizide-metformin and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting the diuretic and adjust antidiabetic therapy as needed. Monitor renal function and potassium periodically.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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