Drug interactions
Glipizide-metformin + Miconazole vaginal
Severity: Moderate
Glipizide-metformin and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP2C9 inhibitor, and even vaginal use can produce measurable systemic absorption in some patients. This can raise glipizide exposure and has been associated with hypoglycemia, particularly with repeated or prolonged use.
What this interaction means in plain words
Glipizide-metformin and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9-mediated glipizide metabolism by absorbed miconazole.
What to do
Advise patients to check blood glucose more often during and shortly after miconazole treatment and to report symptoms of hypoglycemia. Reduce the glipizide dose if glucose falls, or consider a non-azole antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Miconazole vaginal?
MediHelp rates the interaction as moderate. Glipizide-metformin and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole is a CYP2C9 inhibitor, and even vaginal use can produce measurable systemic absorption in some patients. This can raise glipizide exposure and has been associated with hypoglycemia, particularly with repeated or prolonged use.
How serious is the interaction between Glipizide-metformin and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to check blood glucose more often during and shortly after miconazole treatment and to report symptoms of hypoglycemia. Reduce the glipizide dose if glucose falls, or consider a non-azole antifungal.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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