Drug interactions
Glipizide-metformin + Mipomersen
Severity: Moderate
Glipizide-metformin and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen carries a boxed warning for hepatotoxicity, with elevated transaminases and hepatic fat accumulation. Glipizide and metformin are not major hepatotoxins, but overlapping liver injury or reduced hepatic function could complicate diabetes management and raise metformin-related lactic acidosis concerns.
What this interaction means in plain words
Glipizide-metformin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential for hepatic injury; no direct pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin according to the mipomersen REMS schedule. Reassess the need for metformin and sulfonylurea if significant hepatic impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Mipomersen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Mipomersen?
MediHelp rates the interaction as moderate. Glipizide-metformin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen carries a boxed warning for hepatotoxicity, with elevated transaminases and hepatic fat accumulation. Glipizide and metformin are not major hepatotoxins, but overlapping liver injury or reduced hepatic function could complicate diabetes management and raise metformin-related lactic acidosis concerns.
How serious is the interaction between Glipizide-metformin and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin according to the mipomersen REMS schedule. Reassess the need for metformin and sulfonylurea if significant hepatic impairment develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
