Drug interactions
Glipizide-metformin + Norelgestromin
Severity: Minor
Glipizide-metformin and Norelgestromin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives containing progestins and estrogens can modestly impair glucose tolerance and insulin sensitivity. Glycemic control in patients on glipizide and metformin may therefore be slightly reduced.
What this interaction means in plain words
Glipizide-metformin and Norelgestromin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hormonal effects on insulin sensitivity and glucose metabolism antagonize antidiabetic therapy.
What to do
Monitor glucose after starting the patch and adjust antidiabetic therapy if needed. Contraceptive choice should also consider diabetic vascular risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Norelgestromin?
MediHelp rates the interaction as minor. Glipizide-metformin and Norelgestromin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hormonal contraceptives containing progestins and estrogens can modestly impair glucose tolerance and insulin sensitivity. Glycemic control in patients on glipizide and metformin may therefore be slightly reduced.
How serious is the interaction between Glipizide-metformin and Norelgestromin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose after starting the patch and adjust antidiabetic therapy if needed. Contraceptive choice should also consider diabetic vascular risk.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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