Drug interactions
Glipizide-metformin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Glipizide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens may alter glipizide exposure and glycemic control, and HCV cure itself can improve glucose control and lower insulin requirements. Metformin carries a lactic acidosis risk if renal or hepatic function is impaired, and hepatic decompensation in HCV can heighten this.
What this interaction means in plain words
Glipizide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP-mediated changes in glipizide exposure by ritonavir, plus changes in glycemia with HCV treatment; no established metformin pharmacokinetic interaction.
What to do
Monitor glucose closely during and after HCV therapy and reduce antidiabetic doses if hypoglycemia occurs. Check renal and hepatic function and avoid metformin if impairment is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Glipizide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens may alter glipizide exposure and glycemic control, and HCV cure itself can improve glucose control and lower insulin requirements. Metformin carries a lactic acidosis risk if renal or hepatic function is impaired, and hepatic decompensation in HCV can heighten this.
How serious is the interaction between Glipizide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely during and after HCV therapy and reduce antidiabetic doses if hypoglycemia occurs. Check renal and hepatic function and avoid metformin if impairment is significant.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
