Drug interactions
Glipizide-metformin + Oxandrolone
Severity: Moderate
Glipizide-metformin and Oxandrolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxandrolone, an anabolic steroid, can increase insulin sensitivity and lower blood glucose, which may increase the risk of hypoglycemia with glipizide. Metformin alone carries little hypoglycemia risk, so the concern mainly involves the sulfonylurea.
What this interaction means in plain words
Glipizide-metformin and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anabolic androgens alter insulin sensitivity and glucose metabolism, producing additive glucose-lowering effects.
What to do
Monitor blood glucose when oxandrolone is started or stopped, and reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Oxandrolone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxandrolone, an anabolic steroid, can increase insulin sensitivity and lower blood glucose, which may increase the risk of hypoglycemia with glipizide. Metformin alone carries little hypoglycemia risk, so the concern mainly involves the sulfonylurea.
How serious is the interaction between Glipizide-metformin and Oxandrolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when oxandrolone is started or stopped, and reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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