Drug interactions
Glipizide-metformin + Oxymetholone
Severity: Moderate
Glipizide-metformin and Oxymetholone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic androgenic steroids such as oxymetholone can improve insulin sensitivity and lower blood glucose. In patients taking a sulfonylurea plus metformin, this may add to the glucose-lowering effect and occasionally cause hypoglycemia.
What this interaction means in plain words
Glipizide-metformin and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering through enhanced insulin sensitivity (pharmacodynamic synergism).
What to do
Monitor blood glucose more often when oxymetholone is started or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Oxymetholone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic androgenic steroids such as oxymetholone can improve insulin sensitivity and lower blood glucose. In patients taking a sulfonylurea plus metformin, this may add to the glucose-lowering effect and occasionally cause hypoglycemia.
How serious is the interaction between Glipizide-metformin and Oxymetholone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when oxymetholone is started or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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