Drug interactions
Glipizide-metformin + Parecoxib
Severity: Minor
Glipizide-metformin and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs and COX-2 inhibitors may modestly enhance sulfonylurea-induced hypoglycemia, and they can impair renal function, which matters for metformin clearance. The effect is generally small with short perioperative use.
What this interaction means in plain words
Glipizide-metformin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible displacement or reduced clearance of glipizide via prostaglandin inhibition; renal effects may reduce metformin elimination.
What to do
Monitor glucose and renal function, especially in older patients or those with renal impairment, and use the lowest effective parecoxib duration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Parecoxib?
MediHelp rates the interaction as minor. Glipizide-metformin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs and COX-2 inhibitors may modestly enhance sulfonylurea-induced hypoglycemia, and they can impair renal function, which matters for metformin clearance. The effect is generally small with short perioperative use.
How serious is the interaction between Glipizide-metformin and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function, especially in older patients or those with renal impairment, and use the lowest effective parecoxib duration.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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