Drug interactions
Glipizide-metformin + Perindopril
Severity: Moderate
Glipizide-metformin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and increase the risk of hypoglycemia in patients on sulfonylureas or insulin. They may also cause renal function decline, which could increase the risk of metformin accumulation.
What this interaction means in plain words
Glipizide-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
ACE inhibition improves insulin sensitivity via bradykinin-related effects, adding to sulfonylurea glucose lowering.
What to do
Monitor blood glucose, especially after initiation or dose increases. Check renal function periodically and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Glipizide-metformin with Perindopril?
MediHelp rates the interaction as moderate. Glipizide-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and increase the risk of hypoglycemia in patients on sulfonylureas or insulin. They may also cause renal function decline, which could increase the risk of metformin accumulation.
How serious is the interaction between Glipizide-metformin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially after initiation or dose increases. Check renal function periodically and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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