Drug interactions
Glipizide-metformin + Progesterone intravaginal
Severity: Minor
Glipizide-metformin and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestogens may reduce insulin sensitivity, but systemic exposure from intravaginal progesterone is low. Any effect on glycemic control is expected to be small.
What this interaction means in plain words
Glipizide-metformin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone may reduce insulin sensitivity, opposing antidiabetic effect.
What to do
Monitor glucose when therapy is started or stopped and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Progesterone intravaginal?
MediHelp rates the interaction as minor. Glipizide-metformin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestogens may reduce insulin sensitivity, but systemic exposure from intravaginal progesterone is low. Any effect on glycemic control is expected to be small.
How serious is the interaction between Glipizide-metformin and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when therapy is started or stopped and adjust antidiabetic doses if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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