Drug interactions
Glipizide-metformin + Progesterone micronized
Severity: Minor
Glipizide-metformin and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone can modestly reduce insulin sensitivity. The effect on glipizide and metformin efficacy is usually minor.
What this interaction means in plain words
Glipizide-metformin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone-related reduction in insulin sensitivity opposes antidiabetic drugs.
What to do
Monitor glucose after starting or stopping progesterone and adjust antidiabetic therapy as required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Progesterone micronized, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Progesterone micronized?
MediHelp rates the interaction as minor. Glipizide-metformin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral micronized progesterone can modestly reduce insulin sensitivity. The effect on glipizide and metformin efficacy is usually minor.
How serious is the interaction between Glipizide-metformin and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose after starting or stopping progesterone and adjust antidiabetic therapy as required.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
