Drug interactions
Glipizide-metformin + Progesterone natural
Severity: Minor
Glipizide-metformin and Progesterone natural: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Natural progesterone can modestly reduce insulin sensitivity, which may slightly weaken glycemic control with glipizide and metformin. Clinically significant effects are uncommon.
What this interaction means in plain words
Glipizide-metformin and Progesterone natural have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone-related reduction in insulin sensitivity opposes antidiabetic drugs.
What to do
Monitor glucose when starting or stopping progesterone and adjust antidiabetic doses if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Progesterone natural?
MediHelp rates the interaction as minor. Glipizide-metformin and Progesterone natural have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Natural progesterone can modestly reduce insulin sensitivity, which may slightly weaken glycemic control with glipizide and metformin. Clinically significant effects are uncommon.
How serious is the interaction between Glipizide-metformin and Progesterone natural?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping progesterone and adjust antidiabetic doses if control changes.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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