Drug interactions
Glipizide-metformin + Propranolol
Severity: Moderate
Glipizide-metformin and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay recovery from it. It may also impair insulin secretion and raise glucose, which can complicate control.
What this interaction means in plain words
Glipizide-metformin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Nonselective beta blockade blunts adrenergic counter-regulation of hypoglycemia and glycogenolysis.
What to do
Monitor blood glucose more frequently and counsel the patient that sweating may be the main remaining hypoglycemia symptom. Use a cardioselective beta blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Glipizide-metformin with Propranolol?
MediHelp rates the interaction as moderate. Glipizide-metformin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay recovery from it. It may also impair insulin secretion and raise glucose, which can complicate control.
How serious is the interaction between Glipizide-metformin and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and counsel the patient that sweating may be the main remaining hypoglycemia symptom. Use a cardioselective beta blocker if one is needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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