Drug interactions
Glipizide-metformin + Rifampin
Severity: Moderate
Glipizide-metformin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP2C9 and other metabolic enzymes, lowering glipizide concentrations and reducing glucose-lowering effect. Loss of glycemic control may occur, and hypoglycemia can follow rifampin discontinuation.
What this interaction means in plain words
Glipizide-metformin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2C9 increases glipizide metabolism; rifampin may also increase metformin uptake via transporters.
What to do
Monitor glucose when starting rifampin and increase the antidiabetic dose as needed. Reduce the dose again and monitor for hypoglycemia after stopping rifampin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Rifampin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP2C9 and other metabolic enzymes, lowering glipizide concentrations and reducing glucose-lowering effect. Loss of glycemic control may occur, and hypoglycemia can follow rifampin discontinuation.
How serious is the interaction between Glipizide-metformin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting rifampin and increase the antidiabetic dose as needed. Reduce the dose again and monitor for hypoglycemia after stopping rifampin.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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