Drug interactions
Glipizide-metformin + Sage
Severity: Minor
Glipizide-metformin and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage preparations have shown glucose-lowering activity in small studies. Taken with glipizide and metformin, they could add to the hypoglycemic effect.
What this interaction means in plain words
Glipizide-metformin and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucose-lowering activity of sage constituents (pharmacodynamic synergism).
What to do
Monitor blood glucose if the patient uses sage medicinally, and watch for hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Sage?
MediHelp rates the interaction as minor. Glipizide-metformin and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage preparations have shown glucose-lowering activity in small studies. Taken with glipizide and metformin, they could add to the hypoglycemic effect.
How serious is the interaction between Glipizide-metformin and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if the patient uses sage medicinally, and watch for hypoglycemia symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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