Drug interactions
Glipizide-metformin + Salsalate
Severity: Moderate
Glipizide-metformin and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate prodrug, may potentiate the hypoglycemic effect of glipizide. Patients may experience episodes of low blood glucose, particularly at higher salsalate doses.
What this interaction means in plain words
Glipizide-metformin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates have intrinsic glucose-lowering activity and may displace sulfonylureas from plasma protein binding.
What to do
Monitor blood glucose closely when salsalate is started, stopped or its dose changed, and lower the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Salsalate?
MediHelp rates the interaction as moderate. Glipizide-metformin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate prodrug, may potentiate the hypoglycemic effect of glipizide. Patients may experience episodes of low blood glucose, particularly at higher salsalate doses.
How serious is the interaction between Glipizide-metformin and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when salsalate is started, stopped or its dose changed, and lower the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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