Drug interactions
Glipizide-metformin + Selegiline transdermal
Severity: Moderate
Glipizide-metformin and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. At transdermal doses used for depression, selective MAO-B inhibition is lost and the effect is possible.
What this interaction means in plain words
Glipizide-metformin and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may enhance insulin secretion and improve insulin sensitivity; the exact mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping selegiline and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Selegiline transdermal?
MediHelp rates the interaction as moderate. Glipizide-metformin and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. At transdermal doses used for depression, selective MAO-B inhibition is lost and the effect is possible.
How serious is the interaction between Glipizide-metformin and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping selegiline and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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