Drug interactions
Glipizide-metformin + Sulfadiazine
Severity: Moderate
Glipizide-metformin and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfadiazine may increase the hypoglycemic effect of glipizide, and cases of severe hypoglycemia have occurred with sulfonamide and sulfonylurea combinations.
What this interaction means in plain words
Glipizide-metformin and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides can inhibit CYP2C9 metabolism and displace sulfonylureas from plasma protein binding.
What to do
Monitor blood glucose during sulfadiazine therapy and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Sulfadiazine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfadiazine may increase the hypoglycemic effect of glipizide, and cases of severe hypoglycemia have occurred with sulfonamide and sulfonylurea combinations.
How serious is the interaction between Glipizide-metformin and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfadiazine therapy and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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