Drug interactions
Glipizide-metformin + Sulfamethoxazole
Severity: Moderate
Glipizide-metformin and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole, often given with trimethoprim, can enhance the hypoglycemic effect of glipizide. Severe hypoglycemia has been reported, and trimethoprim may also raise metformin levels.
What this interaction means in plain words
Glipizide-metformin and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfamethoxazole inhibits CYP2C9 metabolism of sulfonylureas and may displace them from protein binding.
What to do
Monitor blood glucose closely during co-trimoxazole therapy and reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Glipizide-metformin and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole, often given with trimethoprim, can enhance the hypoglycemic effect of glipizide. Severe hypoglycemia has been reported, and trimethoprim may also raise metformin levels.
How serious is the interaction between Glipizide-metformin and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-trimoxazole therapy and reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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