Drug interactions
Glipizide-metformin + Sulfamethoxypyridazine
Severity: Moderate
Glipizide-metformin and Sulfamethoxypyridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can potentiate sulfonylurea-induced hypoglycemia. Severe hypoglycemia has been reported with sulfonamides and sulfonylureas.
What this interaction means in plain words
Glipizide-metformin and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may displace sulfonylureas from protein binding and inhibit CYP2C9 metabolism, raising glipizide exposure.
What to do
Monitor blood glucose during the antibiotic course and reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Sulfamethoxypyridazine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibacterials can potentiate sulfonylurea-induced hypoglycemia. Severe hypoglycemia has been reported with sulfonamides and sulfonylureas.
How serious is the interaction between Glipizide-metformin and Sulfamethoxypyridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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