Drug interactions
Glipizide-metformin + Tenofovir df
Severity: Moderate
Glipizide-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF may modestly affect metformin exposure, and both drugs can be affected by renal impairment. Tenofovir nephrotoxicity could lead to metformin accumulation and raise the risk of lactic acidosis.
What this interaction means in plain words
Glipizide-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular transport and possible tenofovir-related renal dysfunction reduce metformin clearance.
What to do
Monitor renal function periodically and review metformin dosing if eGFR declines; counsel patients on lactic acidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Glipizide-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF may modestly affect metformin exposure, and both drugs can be affected by renal impairment. Tenofovir nephrotoxicity could lead to metformin accumulation and raise the risk of lactic acidosis.
How serious is the interaction between Glipizide-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and review metformin dosing if eGFR declines; counsel patients on lactic acidosis symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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