Drug interactions
Glipizide-metformin + Trifluoperazine
Severity: Moderate
Glipizide-metformin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can impair glucose tolerance and may reduce the effect of antidiabetic drugs. Glucose control may worsen after starting and hypoglycemia may occur after withdrawal.
What this interaction means in plain words
Glipizide-metformin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antipsychotics can induce insulin resistance and reduce insulin secretion, antagonizing antidiabetic effect.
What to do
Monitor blood glucose when trifluoperazine is started, changed or stopped and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Trifluoperazine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics can impair glucose tolerance and may reduce the effect of antidiabetic drugs. Glucose control may worsen after starting and hypoglycemia may occur after withdrawal.
How serious is the interaction between Glipizide-metformin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trifluoperazine is started, changed or stopped and adjust antidiabetic doses as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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