Drug interactions
Glucagon intranasal + Glyburide-metformin
Severity: Minor
Glucagon intranasal and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and directly opposes the effect of glyburide and metformin. This is the intended effect when used to treat severe hypoglycemia, and the effect is short-lived.
What this interaction means in plain words
Glucagon intranasal and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucagon stimulates hepatic glycogenolysis and gluconeogenesis, pharmacodynamically opposing antidiabetic drugs.
What to do
No dose change is needed when glucagon is used for hypoglycemia rescue. Follow with oral carbohydrate and monitor glucose, since sulfonylurea-induced hypoglycemia can recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glucagon intranasal with Glyburide-metformin?
MediHelp rates the interaction as minor. Glucagon intranasal and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and directly opposes the effect of glyburide and metformin. This is the intended effect when used to treat severe hypoglycemia, and the effect is short-lived.
How serious is the interaction between Glucagon intranasal and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed when glucagon is used for hypoglycemia rescue. Follow with oral carbohydrate and monitor glucose, since sulfonylurea-induced hypoglycemia can recur.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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