Drug interactions
Glucagon intranasal + Insulin degludec-liraglutide
Severity: Minor
Glucagon intranasal and Insulin degludec-liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and directly opposes insulin action. When used as intended to treat severe hypoglycemia this is the desired effect, but it may transiently cause hyperglycemia afterwards.
What this interaction means in plain words
Glucagon intranasal and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis, opposing insulin.
What to do
Use glucagon for severe hypoglycemia as indicated. Give oral carbohydrate once the patient can swallow and recheck glucose, since the effect is temporary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Glucagon intranasal with Insulin degludec-liraglutide?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and directly opposes insulin action. When used as intended to treat severe hypoglycemia this is the desired effect, but it may transiently cause hyperglycemia afterwards.
How serious is the interaction between Glucagon intranasal and Insulin degludec-liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use glucagon for severe hypoglycemia as indicated. Give oral carbohydrate once the patient can swallow and recheck glucose, since the effect is temporary.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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