Drug interactions
Glucagon intranasal + Insulin glargine-lixisenatide
Severity: Minor
Glucagon intranasal and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and directly opposes the action of insulin. When used as rescue therapy for severe hypoglycemia this is the intended effect, but the benefit is temporary.
What this interaction means in plain words
Glucagon intranasal and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis, countering insulin.
What to do
No avoidance is needed when glucagon is used for rescue. After recovery, give oral carbohydrate and monitor glucose, as hypoglycemia from long-acting insulin can recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Glucagon intranasal with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and directly opposes the action of insulin. When used as rescue therapy for severe hypoglycemia this is the intended effect, but the benefit is temporary.
How serious is the interaction between Glucagon intranasal and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No avoidance is needed when glucagon is used for rescue. After recovery, give oral carbohydrate and monitor glucose, as hypoglycemia from long-acting insulin can recur.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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