Drug interactions
Glucagon intranasal + Metformin-repaglinide
Severity: Minor
Glucagon intranasal and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose by stimulating hepatic glycogenolysis and gluconeogenesis, opposing the effect of antidiabetic drugs. When used for severe hypoglycemia, the effect is brief and mainly relevant as a transient rise in glucose. Repaglinide-related hypoglycemia may recur after glucagon wears off.
What this interaction means in plain words
Glucagon intranasal and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: glucagon increases hepatic glucose output, opposing the glucose-lowering effect.
What to do
Give glucagon as indicated for severe hypoglycemia and provide oral carbohydrate afterwards. Monitor glucose for recurrent hypoglycemia, since repaglinide may still be active.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Glucagon intranasal with Metformin-repaglinide?
MediHelp rates the interaction as minor. Glucagon intranasal and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose by stimulating hepatic glycogenolysis and gluconeogenesis, opposing the effect of antidiabetic drugs. When used for severe hypoglycemia, the effect is brief and mainly relevant as a transient rise in glucose. Repaglinide-related hypoglycemia may recur after glucagon wears off.
How serious is the interaction between Glucagon intranasal and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glucagon as indicated for severe hypoglycemia and provide oral carbohydrate afterwards. Monitor glucose for recurrent hypoglycemia, since repaglinide may still be active.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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