Drug interactions
Glyburide-metformin + Hydrocortisone
Severity: Moderate
Glyburide-metformin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids raise blood glucose and can weaken the effect of oral antidiabetic agents. Hyperglycemia may become significant with higher doses or prolonged use, and glucose may fall again when the steroid is reduced.
What this interaction means in plain words
Glyburide-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing the glucose-lowering effects of both drugs.
What to do
Monitor blood glucose more frequently during systemic corticosteroid therapy and increase antidiabetic doses if needed. Reduce doses again when the steroid is tapered to avoid hypoglycemia from glyburide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Glyburide-metformin with Hydrocortisone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids raise blood glucose and can weaken the effect of oral antidiabetic agents. Hyperglycemia may become significant with higher doses or prolonged use, and glucose may fall again when the steroid is reduced.
How serious is the interaction between Glyburide-metformin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during systemic corticosteroid therapy and increase antidiabetic doses if needed. Reduce doses again when the steroid is tapered to avoid hypoglycemia from glyburide.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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