Drug interactions
Glyburide-metformin + Hydroxyprogesterone caproate
Severity: Minor
Glyburide-metformin and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly reduce glucose tolerance, which could weaken the effect of glyburide and metformin. The effect is usually small with hydroxyprogesterone caproate.
What this interaction means in plain words
Glyburide-metformin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestogenic effects may cause mild insulin resistance, opposing antidiabetic drug action.
What to do
Monitor blood glucose when therapy starts or stops. Adjust the antidiabetic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Glyburide-metformin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly reduce glucose tolerance, which could weaken the effect of glyburide and metformin. The effect is usually small with hydroxyprogesterone caproate.
How serious is the interaction between Glyburide-metformin and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when therapy starts or stops. Adjust the antidiabetic dose if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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