Drug interactions
Glyburide-metformin + Insulin degludec / insulin aspart
Severity: Moderate
Glyburide-metformin and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin combined with glyburide and metformin gives additive glucose lowering, and this raises the risk of hypoglycemia, mostly from the sulfonylurea and insulin. The combination is commonly used on purpose but needs dose titration.
What this interaction means in plain words
Glyburide-metformin and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects of exogenous insulin, sulfonylurea-stimulated insulin secretion and metformin-enhanced insulin sensitivity.
What to do
Monitor blood glucose frequently and reduce the insulin or glyburide dose if hypoglycemia occurs. Educate the patient on recognising and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin combined with glyburide and metformin gives additive glucose lowering, and this raises the risk of hypoglycemia, mostly from the sulfonylurea and insulin. The combination is commonly used on purpose but needs dose titration.
How serious is the interaction between Glyburide-metformin and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the insulin or glyburide dose if hypoglycemia occurs. Educate the patient on recognising and treating hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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