Drug interactions
Glyburide-metformin + Insulin inhaled
Severity: Moderate
Glyburide-metformin and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled insulin combined with glyburide and metformin gives additive glucose lowering, which raises the risk of hypoglycemia, mainly from the sulfonylurea and insulin. Dose titration is needed when combining them.
What this interaction means in plain words
Glyburide-metformin and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects of insulin, sulfonylurea-stimulated insulin secretion and metformin-enhanced insulin sensitivity.
What to do
Monitor blood glucose frequently and reduce the glyburide or insulin dose if hypoglycemia occurs. Educate the patient on recognising and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Insulin inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Insulin inhaled?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled insulin combined with glyburide and metformin gives additive glucose lowering, which raises the risk of hypoglycemia, mainly from the sulfonylurea and insulin. Dose titration is needed when combining them.
How serious is the interaction between Glyburide-metformin and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the glyburide or insulin dose if hypoglycemia occurs. Educate the patient on recognising and treating hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
