Drug interactions
Glyburide-metformin + Insulin isophane human / insulin regular human
Severity: Moderate
Glyburide-metformin and Insulin isophane human / insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea and metformin with human insulin produces additive glucose lowering. This is often intentional, but it raises the risk of hypoglycemia, especially when insulin or the oral agents are started or increased, or when meals are missed.
What this interaction means in plain words
Glyburide-metformin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: insulin and glyburide lower glucose through exogenous insulin and enhanced insulin secretion, and metformin reduces hepatic glucose output.
What to do
Monitor blood glucose closely when starting, adjusting or stopping any component, and lower the insulin or glyburide dose if hypoglycemia occurs. Counsel the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea and metformin with human insulin produces additive glucose lowering. This is often intentional, but it raises the risk of hypoglycemia, especially when insulin or the oral agents are started or increased, or when meals are missed.
How serious is the interaction between Glyburide-metformin and Insulin isophane human / insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, adjusting or stopping any component, and lower the insulin or glyburide dose if hypoglycemia occurs. Counsel the patient on recognizing and treating hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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