Drug interactions
Glyburide-metformin + Insulin lispro protamine / insulin lispro
Severity: Moderate
Glyburide-metformin and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using glyburide-metformin with a lispro insulin mix gives additive glucose lowering. This is a common regimen, but hypoglycemia risk rises, particularly at initiation, with dose changes or with irregular meals.
What this interaction means in plain words
Glyburide-metformin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of exogenous insulin, sulfonylurea-stimulated insulin secretion and metformin-mediated reduction in hepatic glucose production.
What to do
Check blood glucose frequently when starting or changing doses and reduce the insulin or glyburide dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using glyburide-metformin with a lispro insulin mix gives additive glucose lowering. This is a common regimen, but hypoglycemia risk rises, particularly at initiation, with dose changes or with irregular meals.
How serious is the interaction between Glyburide-metformin and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose frequently when starting or changing doses and reduce the insulin or glyburide dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition and treatment.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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