Drug interactions
Glyburide-metformin + Insulin lispro
Severity: Moderate
Glyburide-metformin and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining rapid-acting insulin with glyburide-metformin produces additive glucose lowering and raises the risk of hypoglycemia. The combination is commonly used but needs dose coordination.
What this interaction means in plain words
Glyburide-metformin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects of insulin, a sulfonylurea and metformin.
What to do
Monitor blood glucose closely when starting or adjusting therapy and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Insulin lispro
Frequently asked questions
Can I take Glyburide-metformin with Insulin lispro?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining rapid-acting insulin with glyburide-metformin produces additive glucose lowering and raises the risk of hypoglycemia. The combination is commonly used but needs dose coordination.
How serious is the interaction between Glyburide-metformin and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting therapy and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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