Drug interactions
Glyburide-metformin + Insulin regular human
Severity: Moderate
Glyburide-metformin and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular insulin added to glyburide-metformin produces additive glucose lowering. The combination is widely used but increases the chance of hypoglycemia, especially when doses change or meals are delayed.
What this interaction means in plain words
Glyburide-metformin and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of exogenous insulin, sulfonylurea-stimulated insulin release and metformin's suppression of hepatic glucose production.
What to do
Monitor blood glucose closely at initiation and with dose changes, and decrease the insulin or glyburide dose if hypoglycemia occurs. Teach the patient to recognize and treat low glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Insulin regular human?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular insulin added to glyburide-metformin produces additive glucose lowering. The combination is widely used but increases the chance of hypoglycemia, especially when doses change or meals are delayed.
How serious is the interaction between Glyburide-metformin and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely at initiation and with dose changes, and decrease the insulin or glyburide dose if hypoglycemia occurs. Teach the patient to recognize and treat low glucose.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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