Drug interactions
Glyburide-metformin + Iodixanol
Severity: Major
Glyburide-metformin and Iodixanol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravascular iodinated contrast can cause acute kidney injury, reducing metformin clearance and raising the risk of lactic acidosis. Risk is highest in patients with reduced eGFR or with intra-arterial dosing.
What this interaction means in plain words
Glyburide-metformin and Iodixanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-associated nephropathy reduces renal elimination of metformin, causing accumulation and lactic acidosis.
What to do
Hold metformin at the time of or before the procedure in patients with eGFR below 30, liver disease, or intra-arterial contrast. Resume after 48 hours once renal function is confirmed stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Iodixanol?
MediHelp rates the interaction as major. Glyburide-metformin and Iodixanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, reducing metformin clearance and raising the risk of lactic acidosis. Risk is highest in patients with reduced eGFR or with intra-arterial dosing.
How serious is the interaction between Glyburide-metformin and Iodixanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR below 30, liver disease, or intra-arterial contrast. Resume after 48 hours once renal function is confirmed stable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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