Drug interactions
Glyburide-metformin + Ioversol
Severity: Major
Glyburide-metformin and Ioversol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioversol is an iodinated contrast agent that can impair renal function and reduce metformin elimination. This raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Glyburide-metformin and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-associated kidney injury decreases renal metformin clearance.
What to do
Withhold metformin at the time of imaging in at-risk patients and for 48 hours afterward; restart after renal function is rechecked and stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Ioversol?
MediHelp rates the interaction as major. Glyburide-metformin and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ioversol is an iodinated contrast agent that can impair renal function and reduce metformin elimination. This raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Glyburide-metformin and Ioversol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold metformin at the time of imaging in at-risk patients and for 48 hours afterward; restart after renal function is rechecked and stable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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