Drug interactions
Glyburide-metformin + Isoniazid
Severity: Moderate
Glyburide-metformin and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic drugs. Glycemic control may deteriorate during treatment and recover after it is stopped.
What this interaction means in plain words
Glyburide-metformin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Mechanism is not well established; isoniazid may impair carbohydrate metabolism and cause hyperglycemia.
What to do
Monitor blood glucose during isoniazid therapy and adjust antidiabetic doses as needed. Watch for hypoglycemia when isoniazid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Isoniazid
Frequently asked questions
Can I take Glyburide-metformin with Isoniazid?
MediHelp rates the interaction as moderate. Glyburide-metformin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic drugs. Glycemic control may deteriorate during treatment and recover after it is stopped.
How serious is the interaction between Glyburide-metformin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during isoniazid therapy and adjust antidiabetic doses as needed. Watch for hypoglycemia when isoniazid is stopped.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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