Drug interactions
Glyburide-metformin + Isradipine
Severity: Minor
Glyburide-metformin and Isradipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers such as isradipine can occasionally worsen glycemic control in patients taking antidiabetic drugs. The effect is usually small and variable, but glucose may rise after starting the drug.
What this interaction means in plain words
Glyburide-metformin and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcium channel blockade may modestly impair insulin secretion and peripheral insulin sensitivity; the mechanism is not firmly established.
What to do
Check blood glucose after starting or stopping isradipine and adjust antidiabetic doses if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Isradipine?
MediHelp rates the interaction as minor. Glyburide-metformin and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers such as isradipine can occasionally worsen glycemic control in patients taking antidiabetic drugs. The effect is usually small and variable, but glucose may rise after starting the drug.
How serious is the interaction between Glyburide-metformin and Isradipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose after starting or stopping isradipine and adjust antidiabetic doses if control changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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