Drug interactions
Glyburide-metformin + Ketorolac intranasal
Severity: Moderate
Glyburide-metformin and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea-induced hypoglycemia in some reports. With short-term intranasal ketorolac the effect is likely small, but renal effects of ketorolac may also matter for metformin accumulation in patients with kidney impairment.
What this interaction means in plain words
Glyburide-metformin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible displacement of glyburide from protein binding and prostaglandin-related effects on insulin secretion; ketorolac may also reduce renal function, impairing metformin elimination.
What to do
Monitor blood glucose and renal function during ketorolac use, and avoid it in patients with reduced kidney function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can potentiate sulfonylurea-induced hypoglycemia in some reports. With short-term intranasal ketorolac the effect is likely small, but renal effects of ketorolac may also matter for metformin accumulation in patients with kidney impairment.
How serious is the interaction between Glyburide-metformin and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during ketorolac use, and avoid it in patients with reduced kidney function.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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