Drug interactions
Glyburide-metformin + Ketorolac
Severity: Moderate
Glyburide-metformin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ketorolac may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Ketorolac can also impair renal function, which may raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Glyburide-metformin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Possible displacement of glyburide from plasma protein binding and NSAID-related reduction in renal function that reduces metformin clearance.
What to do
Monitor blood glucose and renal function when ketorolac is used, and keep the course short. Reduce the glyburide dose if hypoglycemia occurs and stop metformin if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Ketorolac?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ketorolac may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Ketorolac can also impair renal function, which may raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Glyburide-metformin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when ketorolac is used, and keep the course short. Reduce the glyburide dose if hypoglycemia occurs and stop metformin if renal function deteriorates.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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