Drug interactions
Glyburide-metformin + Lumacaftor / ivacaftor
Severity: Moderate
Glyburide-metformin and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may also induce CYP2C9, which could lower glyburide concentrations. Reduced glucose control is possible, although CYP2C9 effects are less certain. Ivacaftor and lumacaftor may also alter transporter activity.
What this interaction means in plain words
Glyburide-metformin and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9 and other enzymes, increasing glyburide clearance.
What to do
Monitor blood glucose after starting lumacaftor/ivacaftor. Adjust the glyburide dose as needed for lost efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Glyburide-metformin and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may also induce CYP2C9, which could lower glyburide concentrations. Reduced glucose control is possible, although CYP2C9 effects are less certain. Ivacaftor and lumacaftor may also alter transporter activity.
How serious is the interaction between Glyburide-metformin and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting lumacaftor/ivacaftor. Adjust the glyburide dose as needed for lost efficacy.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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