Drug interactions
Glyburide-metformin + Maitake
Severity: Moderate
Glyburide-metformin and Maitake: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom extracts have lowered blood glucose in animal studies. Used with glyburide-metformin they might add to the glucose-lowering effect, so hypoglycemia is possible, though human evidence is limited.
What this interaction means in plain words
Glyburide-metformin and Maitake can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effect, possibly through improved insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose closely if maitake supplements are used, and lower the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Maitake?
MediHelp rates the interaction as moderate. Glyburide-metformin and Maitake can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maitake mushroom extracts have lowered blood glucose in animal studies. Used with glyburide-metformin they might add to the glucose-lowering effect, so hypoglycemia is possible, though human evidence is limited.
How serious is the interaction between Glyburide-metformin and Maitake?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely if maitake supplements are used, and lower the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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