Drug interactions
Glyburide-metformin + Meclofenamate
Severity: Moderate
Glyburide-metformin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the hypoglycemic effect of sulfonylureas in some patients. Renal effects of NSAIDs can also impair metformin clearance in susceptible patients.
What this interaction means in plain words
Glyburide-metformin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible protein-binding displacement of glyburide and prostaglandin inhibition affecting insulin secretion; reduced renal function may impair metformin elimination.
What to do
Monitor blood glucose and renal function when meclofenamate is used and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Meclofenamate?
MediHelp rates the interaction as moderate. Glyburide-metformin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the hypoglycemic effect of sulfonylureas in some patients. Renal effects of NSAIDs can also impair metformin clearance in susceptible patients.
How serious is the interaction between Glyburide-metformin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when meclofenamate is used and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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