Drug interactions
Glyburide-metformin + Methylene blue
Severity: Moderate
Glyburide-metformin and Methylene blue: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylene blue is a MATE and OCT2 inhibitor in vitro and may raise metformin exposure. Higher metformin levels could increase the risk of lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Glyburide-metformin and Methylene blue can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methylene blue may inhibit OCT2 and MATE transporters, reducing renal elimination of metformin.
What to do
Monitor renal function and for lactic acidosis symptoms after methylene blue. Consider holding metformin if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Methylene blue?
MediHelp rates the interaction as moderate. Glyburide-metformin and Methylene blue can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylene blue is a MATE and OCT2 inhibitor in vitro and may raise metformin exposure. Higher metformin levels could increase the risk of lactic acidosis, especially in renal impairment.
How serious is the interaction between Glyburide-metformin and Methylene blue?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for lactic acidosis symptoms after methylene blue. Consider holding metformin if renal function is impaired.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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