Drug interactions
Glyburide-metformin + Mipomersen
Severity: Moderate
Glyburide-metformin and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation. Glyburide can also rarely cause liver injury, so combined use may add to hepatic risk.
What this interaction means in plain words
Glyburide-metformin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin per mipomersen labeling and review therapy if enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Mipomersen?
MediHelp rates the interaction as moderate. Glyburide-metformin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation. Glyburide can also rarely cause liver injury, so combined use may add to hepatic risk.
How serious is the interaction between Glyburide-metformin and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin per mipomersen labeling and review therapy if enzymes rise significantly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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