Drug interactions
Glyburide-metformin + Norelgestromin
Severity: Minor
Glyburide-metformin and Norelgestromin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives may slightly impair glucose tolerance, which can reduce the effect of antidiabetic drugs. With low-dose modern products the effect is usually small.
What this interaction means in plain words
Glyburide-metformin and Norelgestromin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestin and estrogen effects can reduce insulin sensitivity, mildly opposing antidiabetic action.
What to do
Monitor glucose when starting or stopping the contraceptive and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Norelgestromin?
MediHelp rates the interaction as minor. Glyburide-metformin and Norelgestromin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hormonal contraceptives may slightly impair glucose tolerance, which can reduce the effect of antidiabetic drugs. With low-dose modern products the effect is usually small.
How serious is the interaction between Glyburide-metformin and Norelgestromin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping the contraceptive and adjust antidiabetic therapy if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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