Drug interactions
Glyburide-metformin + Octreotide
Severity: Moderate
Glyburide-metformin and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can cause either hypoglycemia or hyperglycemia in diabetic patients. Requirements for glyburide-metformin may change after octreotide is started or adjusted.
What this interaction means in plain words
Glyburide-metformin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Octreotide inhibits insulin and counter-regulatory hormone secretion, altering glucose control through pharmacodynamic effects.
What to do
Monitor blood glucose frequently when starting, changing or stopping octreotide and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Octreotide
Frequently asked questions
Can I take Glyburide-metformin with Octreotide?
MediHelp rates the interaction as moderate. Glyburide-metformin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can cause either hypoglycemia or hyperglycemia in diabetic patients. Requirements for glyburide-metformin may change after octreotide is started or adjusted.
How serious is the interaction between Glyburide-metformin and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting, changing or stopping octreotide and adjust antidiabetic doses accordingly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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