Drug interactions
Glyburide-metformin + Olanzapine
Severity: Moderate
Glyburide-metformin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is associated with weight gain, insulin resistance and hyperglycemia, which can reduce the effectiveness of glyburide-metformin. Diabetic control may deteriorate, occasionally severely.
What this interaction means in plain words
Glyburide-metformin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine causes metabolic effects including insulin resistance, opposing the glucose-lowering action of the antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during olanzapine therapy and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Olanzapine
Frequently asked questions
Can I take Glyburide-metformin with Olanzapine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is associated with weight gain, insulin resistance and hyperglycemia, which can reduce the effectiveness of glyburide-metformin. Diabetic control may deteriorate, occasionally severely.
How serious is the interaction between Glyburide-metformin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during olanzapine therapy and intensify antidiabetic treatment as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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