Drug interactions
Glyburide-metformin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Glyburide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen has no well-established effect on metformin, but ritonavir-containing products may affect glucose and transporters. Glyburide exposure could also change through transporter and enzyme effects, altering glycemic control.
What this interaction means in plain words
Glyburide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of transporters and enzymes (e.g., OATP, CYP) by the regimen may alter glyburide exposure; the effect on metformin is not clearly established.
What to do
Monitor blood glucose and renal function when starting or stopping the regimen, and adjust the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This regimen has no well-established effect on metformin, but ritonavir-containing products may affect glucose and transporters. Glyburide exposure could also change through transporter and enzyme effects, altering glycemic control.
How serious is the interaction between Glyburide-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or stopping the regimen, and adjust the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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